Trials and tribulations: so many potential treatments, so few answers

How Do so Few Control so Many?

The separation of sister chromatids at the metaphase-to-anaphase transition is triggered by a protease called separase that is activated by the destruction of an inhibitory chaperone (securin). This process is mediated by a ubiquitin protein ligase called the anaphase-promoting complex or cyclosome (APC/C), along with a protein called Cdc20. It is vital that separase not be activated before eve...

If so many are “few,” how few are “many”?

The scope of reference of a word's meaning can be highly variable. We present a novel paradigm to investigate the flexible interpretation of word meaning. We focus on quantifiers such as "many" or "few," a class of words that depends on number knowledge but can be interpreted in a flexible manner. Healthy young adults performed a truth value judgment task on pictorial arrays of varying amounts ...

So few pulsars, so few females.

So Many users - So Many Perspectives

Visualization — the transformation of data and information into multimedia including pictures, animation and 3D scenes — enables users to understand information more naturally. It reveals patterns and relations in the information which may otherwise remain hidden. As a consequence, it can provide a single user with enough valuable information to support decision making. In addition to this, vis...

Toxin-antitoxin genes of the Gram-positive pathogen Streptococcus pneumoniae: so few and yet so many.

Pneumococcal infections cause up to 2 million deaths annually and raise a large economic burden and thus constitute an important threat to mankind. Because of the increase in the antibiotic resistance of Streptococcus pneumoniae clinical isolates, there is an urgent need to find new antimicrobial approaches to triumph over pneumococcal infections. Toxin-antitoxin (TA) systems (TAS), which are p...